Nedocromil

Mast cell stabilisers

Antihistamines block the effects of histamine already released into the system. Another means of blocking the effects of histamine is by preventing its release from inflammatory cells. Nedocromil and cromoglycate

are substances that are thought to work by preventing degranulation of mast cells. These agents are only available by inhalation and are indicated for the prophylaxis of mild asthma. Unfortunately, poor clinical results with these agents limit their utility.

1

Mast cell stabilizers block the Ca++ mediated release of storage vesicles. 

2

Nedocromil prevents the IgE/antigen complex from binding to the mast cell.