Parkinson's disease

Parkinson's

In this graphic, the effects of Parkinson's disease are shown. Parkinson's causes the death of numerous dopamine neurons in the substantia nigra. The subsequent decrease in dopamine output to the striatum affects the entire dopamine network. The input to the thalamus is increasingly inhibitory, resulting in less stimulating signals towards the frontal cortex and thus muscles.

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I. Parkinson’s disease can be treated with DA agonists. II. Parkinson’s disease can be treated with cholinergic agonists. 

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In Parkinson’s disease