TH1-cell dependent response

TH1 cell dependent response

The bulk of the pathogen-specific antibodies come from B-cells stimulated by thymus-dependent (TD) antigens. Activation of these B cells occurs in the secondary lymphoid tissue where B cells, specific antigen and CD4-T helper cells are brought together. CD4-T cells can differentiate along two pathways giving rise to either CD4 TH1 or TH2 cells. The cytokines produced by effector TH1 or TH2 cells also tend

to suppress each other, pointing the response in one direction.

TH1 cells give the most effective response to microorganisms. They secrete cytokines that activate macrophages, which then destroy the bacteria they contain. They also activate B cells to produce opsonizing antibodies such as IgG1.

Text taken from “the immune system”, Parham, Garland Publishing 2000page 142,143.

1

T-helper cells are the most effective response to micro-organisms because they: 

2

Infection with Mycobacterium tuberculosis evokes which of the following cytokine profiles?