Alzheimer's disease

Alzheimer's disease

Alzheimer's disease is the most common dementing disorder. The pathophysiology remains unknown, although several features are associated with its presence. These include genetic factors, excessive NMDA stimulation, a reduction in choline acetyltransferase activity, the presence of amyloid-beta plaques, and neurofibrillary tangles and neuroinflammation. These changes seem to start in the nucleus basalis of Meynert and progress through

the cortex. This leads to a progressive, irreversible, neurodegenerative illness with cognitive loss, behavioural changes and a loss in independence being the major clinical symptoms.

Treatment of Alzheimer's disease

1

In Alzheimer’s disease, it is in the interest of the patient to ________ the effects of acetylcholine.

2

In Alzheimer’s disease, it is in the interest of the patient to __________ the glutamate activity at the NMDA receptor. 

3

Which of the following is NOT a criteria for dementia?