Anti-emetics

Anti-emetics

This figure shows the different sites of actions of anti-emetics. The agents used to treat emesis generally exert their effect by blocking one neurotransmitter receptor and can thus be grouped into classes of dopamine D2 antagonists,serotonin

5-HT3antagonists and anticholinergics. The exception to this is the drugmetoclopramidewhich has both D2- and 5-HT3-antagonist activity. Note that some drugs act on the level of the CNS, others on the level of the GI tract, and yet others on both the CNS and GI tract. More information about these agents is depicted in the following graphics.

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A patient receives a prophylactic dose of droperidol near the end of surgery. In the recovery room, the patient becomes nauseated and vomits. What do you recommend?