α-adrenergic receptor agonists

α-adrenergic receptor agonists

α-sympathicomimetics or α-adrenergic receptor agonists such as phenylpropanolamine and ephedrine increase intraurethral pressure. The α-adrenergic receptors in bladder and proximal urethra are stimulated. This stimulation will evoke an increased tone of the sphincter mechanism and thus improve closure of the bladder.

1

I α-adrenergic receptor agonists used in the treatment of incontinence do NOT have systemic adverse effects. II ephedrine may be effective when used prophylactically in certain stress situations.