Glucocorticoids in the eye
Glucocorticoids have a small area of application in the treatment of ocular infections. A correct diagnosis is important, since corticosteroids can worsen herpes simplex infection. Indications for the use of corticosteroids are different kinds of keratitis, iritis, cyclitis, and iridocyclitis. Corticosteroids exert their action after binding to a glucocorticoid receptor and interaction with the DNA. They alter the immune response. Prednisolon
and dexamethason are mostly used for applications in the eye. These drugs should only be used for a short time, because prolonged use can lead to glaucoma and cataracts. Another risk of corticosteroid therapy in the eye is masking or exacerbation of viral or fungal infections.